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 User Description: Complete recovery in all animals occurred within 1—1. Of the next studies, the repeated-dose toxicity studies that had been deemed to be most relevant to the chance evaluation are summarized in Appendix 6. In a study carried out by NTP , five female and male F rats were dosed with resorcinol in deionized water by way of gavage at zero, High-dose females had considerably decreased absolute and relative thymus weights. No other biologically important variations in organ weights had been noticed. In distinction to those findings, Eastin et al.The elimination was biphasic, with half-lives of 18—21 min and eight. The 14 C activity was quickly distributed in major tissues corresponding to muscle tissue, kidneys, and liver, without indication of bioaccumulation Merker et al. Any new information being supplied in the midst of the OECD assessment might be provided to the IPCS in order that an addendum could be ready for consideration.A focus of 0. These substances have been found to be potent inhibitors of thyroid peroxidase or I organification. aste modena in addition to 2- and 5-methylresorcinol were reported to be At an iodide focus of zero.Different studies carried out with rats and mice gave no enhance within the micronucleus formation in bone marrow cells. Bone marrow smears were prepared at 30 h, and polychromatic erythrocytes per animal were scored Gocke et al. An interim sacrifice at 15 months gave no distinction in haematology, scientific chemistry, or other clinical pathology parameters and no increased incidence of neoplasms or non-neoplastic lesions. Also, at ultimate sacrifice, there was no proof of carcinogenic exercise in males or females of each species.These figures agree properly with the above publicity estimate based mostly on the Yeung et al.From the scarce information obtainable, using resorcinol in hair dyes 0. The use of anti-zits cream is taken as the state of affairs of most concern due to the chance of continuous exposure.In both species, there have been no opposed effects on ultimate mean physique weights, haematology, or medical chemistry parameters, and no chemical-associated gross or microscopic lesions had been observed. In another study, rats were exposed to 0 or 0. No thyroid hormone measurements were carried out.No resorcinol-related macroscopic findings, organ weight, or antagonistic microscopic goal organ effects were noticed within the F zero and F 1 parental animals. The F 0 and F 1 females continued to obtain the resorcinol all through mating, gestation, and lactation and thru the day of euthanasia for study design, see Appendix 7. There have been no F zero and F 1 parental resorcinol-related deaths or scientific findings through the weekly detailed physical examinations. In controls and the high-dose group, a qualitative histopathological evaluation of the mind forebrain, midbrain, and hindbrain was additionally performed for the aforementioned animals RTF, There have been no antagonistic effects regarding reproductive efficiency, mortality, and body or organ weights.British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The effect of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there are not any epidemiological data related to the carcinogenicity of resorcinol in people and that the proof of its carcinogenicity in animals is inadequate; thus, resorcinol isn't classifiable as to its carcinogenicity to people. JECFA assessed the hazards from the use of resorcinol as a meals flavouring agent and concluded that this use is of no safety concern. Overall, the studies are not adequate for a statistical extrapolation method according to the EU Technical Guidance Document EC, a.Animals have been maintained for a number of months with periodic sacrifices Flickinger, The animals have been then examined weekly for 10 further weeks. Sacrificed animals confirmed brown-dyed abdomen partitions and filling of abdomen and small intestine with a darkish-brown to orange substance. pvp bologna weren't noted in survivors.For the benthic and terrestrial compartments, the available toxicity data cannot be considered sufficient for a quantitative danger characterization. However, these compartments are less relevant for resorcinol, due to marginal releases and emissions to these compartments as well as a very low potential for adsorption of resorcinol to natural matter.